Incazelo
Lokhu kungafezwa ngezindlela ezihlukahlukene, okuhlanganisa ukukhomba izindlela ezithile ze-biochemical, ukulungisa izimpendulo zamasosha omzimba, noma ukubulala ngokuqondile noma ukuvimbela ukukhula kwamagciwane. Okunye okucatshangelwayo okubalulekile ekwelashweni kwezidakamizwa okusebenzayo ukuqonda okuphelele kwezinhlobo zezilwane ezilashwayo. Izinhlobo ezehlukene zingase zibe nomehluko obalulekile we-anatomical, physiological, kanye ne-metabolic ethinta ukumuncwa kwezidakamizwa, ukusatshalaliswa, i-metabolism, kanye nokuphuma kwezidakamizwa. Isibonelo, i-pH yamathumbu, umsebenzi we-enzyme, nokusebenza kwezinso kuyahlukahluka phakathi kwezinhlobo zezilwane, okuthinta i-pharmacokinetics yezidakamizwa nokusebenza kahle. Ngaphezu kwalokho, izici ezinjengobudala nobulili zingase zithinte i-metabolism yezidakamizwa, futhi umthamo noma imvamisa yomthamo kungase kudingeke ukuthi kulungiswe. Ngaphezu kwalokho, isifo esithile esilashwayo kanye nenqubo yaso eyisisekelo ye-pathological kufanele kubhekwe lapho kukhethwa umuthi ofanele. I-etiology, i-pathogenesis, kanye nokubonakaliswa komtholampilo kwezifo kuyahlukahluka. Ukuqonda izindlela zezifo kubalulekile ekukhetheni izidakamizwa eziqondise kumagciwane athile noma ukubhekana nezinqubo ezithile ze-pathological. Ngaphezu kwalokho, isigaba sesifo, ukuqina, kanye nezinga lokulimala kwezicubu kufanele kucatshangelwe ukuze kuqinisekiswe ukucatshangelwa kokwelashwa okufanele. Ukwakhiwa komuthi, okuhlanganisa nefomu lawo lomthamo, nakho kudlala indima ebalulekile. Amafomu emithamo ahlukene, njengamaphilisi omlomo, izixazululo zomjovo noma okhilimu basendaweni, anemininingwane ehlukene ye-bioavailability kanye ne-pharmacokinetic. Izinto ezinjengokuncibilika kwezidakamizwa, ukuzinza, kanye nomzila ohlosiwe wokuphatha kufanele kucatshangelwe lapho kukhethwa ifomu lomthamo elifanele.
Umthamo kanye nomzila wokuphatha kubalulekile ekuzuzeni umphumela wokwelapha nokugwema imiphumela emibi. Umthamo kufanele unqunywe ngokuya ngezinto ezifana nezinhlobo zezilwane, isisindo somzimba, ubudala, ubunzima besifo, kanye nezakhiwo ze-pharmacokinetic kanye ne-pharmacodynamic zomuthi. Ukwengeza, umzila wokuphatha kufanele ukhethwe ngokusekelwe ezicini ezifana nokuqala okufunwayo kwesenzo, izici zokumuncwa kwezidakamizwa kanye nokusabalalisa, kanye nesimo somzimba wesilwane. Kafushane, ukusetshenziswa kwezidakamizwa ukwelapha izifo zezilwane kudinga ukuqonda okuphelele kwezilwane, izifo, nezidakamizwa. Lolu lwazi luhlanganisa ukucatshangelwa kwezinto ezifana nezinhlobo zezilwane, ubudala, ubulili, uhlobo lwesifo kanye ne-pathology, ifomu lomthamo, umthamo, kanye nomzila wokuphatha.
Iphakheji: Isiqephu ngasinye esine-poly bag, izingcezu ezingama-200 ezinebhokisi lokuthekelisa.
