Inkcazo
Oku kunokufezekiswa ngeendlela ezahlukeneyo, kubandakanywa ukujolisa kwiindlela ezithile ze-biochemical, ukumodareyitha iimpendulo ze-immune, okanye ukubulala ngokuthe ngqo okanye ukuvimbela ukukhula kwee-pathogens. Enye yeengqwalasela eziphambili kunyango olusebenzayo lwamachiza kukuqonda ngokucokisekileyo uhlobo oluthile lwesilwanyana esinyangwayo. Iindidi ezahlukeneyo zinokuba neeyantlukwano ezibalulekileyo ze-anatomical, physiological, kunye ne-metabolic echaphazela ukufunxwa kweziyobisi, ukuhanjiswa, i-metabolism, kunye nokukhupha. Ngokomzekelo, i-pH yesisu, umsebenzi we-enzyme, kunye nokusebenza kwezintso kuyahluka phakathi kweentlobo, ezichaphazela i-pharmacokinetics yeziyobisi kunye nokusebenza kakuhle. Ukongeza, izinto ezinje ngobudala kunye nesini zinokuchaphazela i-metabolism yeziyobisi, kunye nedosi okanye i-dosing frequency inokufuna ukulungiswa. Ngaphezu koko, isifo esithile esiphathwayo kunye nenkqubo ye-pathological esisiseko kufuneka ithathelwe ingqalelo xa ukhetha ichiza elifanelekileyo. I-etiology, i-pathogenesis, kunye nezibonakaliso zeklinikhi zezifo ziyahluka. Ukuqonda iindlela zesifo kubalulekile ekukhetheni amachiza ajolise kwiintsholongwane ezithile okanye ukujongana neenkqubo ezithile ze-pathological. Ukongeza, inqanaba lesifo, ubukhali, kunye nobungakanani bomonakalo wezicubu kufuneka ziqwalaselwe ukuqinisekisa ukuqwalaselwa okufanelekileyo konyango. Ukwenziwa kwechiza, kubandakanywa nefom yedosi, nayo idlala indima ebalulekileyo. Iifom ezahlukeneyo zedosi, ezinje ngeepilisi zomlomo, izisombululo zenaliti okanye iikhrimu ze-topical, zineeprofayili ezahlukeneyo ze-bioavailability kunye ne-pharmacokinetic. Imiba efana nokunyibilika kwechiza, uzinzo, kunye nendlela ecetywayo yolawulo kufuneka iqwalaselwe xa kukhethwa ifomu yedosi efanelekileyo.
Umthamo kunye nendlela yokulawula ibalulekile ekufezekiseni umphumo wonyango kunye nokuphepha iziphumo ezibi. Umthamo kufuneka unqunywe ngokwezinto ezifana neentlobo zezilwanyana, ubunzima bomzimba, ubudala, ubunzima besifo, kunye neempawu ze-pharmacokinetic kunye ne-pharmacodynamic yeziyobisi. Ukongezelela, indlela yokulawula kufuneka ikhethwe ngokusekelwe kwizinto ezifana nokufunwa kwesenzo, ukufunxa iziyobisi kunye neempawu zokusabalalisa, kunye nesimo somzimba wesilwanyana. Isishwankathelo, ukusetyenziswa kweziyobisi ukunyanga izifo zezilwanyana kufuna ukuqonda okubanzi kwezilwanyana, izifo kunye neziyobisi. Olu lwazi lubandakanya ukuqwalaselwa kwezinto ezifana neentlobo zezilwanyana, ubudala, isondo, uhlobo lwesifo kunye ne-pathology, ifom yedosi, umthamo, kunye nendlela yokulawula.
Ipakethe: Isiqwenga ngasinye sinengxowa eninzi, iziqwenga ezingama-200 ezinebhokisi yokuthumela ngaphandle.
