SDAL27 Iplastiki yokutya izilwanyana iBalling Guns

Oku kunokufezekiswa ngeendlela ezahlukeneyo, kubandakanywa ukujolisa kwiindlela ezithile ze-biochemical, ukumodareyitha iimpendulo ze-immune, okanye ukubulala ngokuthe ngqo okanye ukuvimbela ukukhula kwee-pathogens. Enye yeengqwalasela eziphambili kunyango olusebenzayo lwamachiza kukuqonda ngokucokisekileyo uhlobo oluthile lwesilwanyana esinyangwayo. Iindidi ezahlukeneyo zinokuba neeyantlukwano ezibalulekileyo ze-anatomical, physiological, kunye ne-metabolic echaphazela ukufunxwa kwechiza, ukuhanjiswa, imetabolism, kunye nokukhupha. Ngokomzekelo, i-pH yesisu, umsebenzi we-enzyme, kunye nokusebenza kwezintso kuyahluka phakathi kweentlobo, ezichaphazela i-pharmacokinetics yeziyobisi kunye nokusebenza kakuhle. Ukongeza, izinto ezinje ngobudala kunye nesini zinokuchaphazela i-metabolism yeziyobisi, kwaye idosi okanye i-dosing frequency inokufuna ukulungiswa. Ngaphezu koko, isifo esithile esiphathwayo kunye nenkqubo ye-pathological esisiseko kufuneka ithathelwe ingqalelo xa ukhetha ichiza elifanelekileyo. I-etiology, i-pathogenesis, kunye nezibonakaliso zeklinikhi zezifo ziyahluka. Ukuqonda iindlela zesifo kubalulekile ekukhetheni amachiza ajolise kwiintsholongwane ezithile okanye ukujongana neenkqubo ezithile ze-pathological. Ukongeza, inqanaba lesifo, ubukhali, kunye nobungakanani bomonakalo wezicubu kufuneka ziqwalaselwe ukuqinisekisa ukuqwalaselwa okufanelekileyo konyango. Ukwenziwa kwechiza, kubandakanywa nefom yedosi, nayo idlala indima ebalulekileyo. Iifom ezahlukeneyo zedosi, ezinje ngeepilisi zomlomo, izisombululo zenaliti okanye iikhrimu ze-topical, zineeprofayili ezahlukeneyo ze-bioavailability kunye ne-pharmacokinetic. Izinto ezinjengokunyibilika kwechiza, uzinzo, kunye nendlela ecetywayo yolawulo kufuneka ziqwalaselwe xa kukhethwa ifomu yedosi efanelekileyo.