Tlhaloso
Sena se ka finyelloa ka mekhoa e sa tšoaneng, ho kenyelletsa ho lebisa tlhokomelo litseleng tse khethehileng tsa lik'hemik'hale, ho fetola likarabo tsa 'mele oa ho itšireletsa mafung, kapa ho bolaea ka ho toba kapa ho thibela kholo ea likokoana-hloko. E 'ngoe ea lintlha tsa bohlokoa bakeng sa phekolo e sebetsang ea lithethefatsi ke kutloisiso e feletseng ea mefuta e itseng ea liphoofolo e phekoloang. Mefuta e fapaneng e kanna ea ba le liphapano tse kholo tsa anatomical, physiological, le metabolism tse amang ho monya, ho ajoa, metabolism, le ho ntšoa ha lithethefatsi. Mohlala, pH ea mala, tšebetso ea enzyme, le ts'ebetso ea renal li fapana ho ea ka mefuta, e ama pharmacokinetics ea lithethefatsi le ts'ebetso ea eona. Ho feta moo, lintlha tse kang lilemo le bong le tsona li ka ama metabolism ea lithethefatsi, 'me tekanyo ea litekanyetso kapa makhetlo a ho noa a ka hloka ho lokisoa. Ho feta moo, lefu le itseng le phekoloang le ts'ebetso ea lona ea motheo ea pathological e tlameha ho nkoa ha ho khethoa moriana o nepahetseng. Etiology, pathogenesis le lipontšo tsa kliniki tsa mafu li fapana. Ho utloisisa mekhoa ea mafu ho bohlokoa bakeng sa ho khetha lithethefatsi tse lebisang likokoana-hloko tse itseng kapa ho sebetsana le mekhoa e itseng ea pathological. Ho phaella moo, boemo ba lefu, ho teba, le boholo ba tšenyo ea lisele li lokela ho nahanoa ho etsa bonnete ba hore ho nahanoa ka mokhoa o nepahetseng oa phekolo. Ho etsoa ha moriana, ho kenyeletsa le mokhoa oa oona oa tekanyo, le hona ho phetha karolo ea bohlokoa. Mefuta e fapaneng ea litekanyetso, joalo ka matlapa a molomo, litharollo tsa ente kapa litlolo tsa topical, li na le lintlha tse fapaneng tsa bioavailability le pharmacokinetic. Lintlha tse kang ho qhibiliha ha lithethefatsi, botsitso, le tsela e reretsoeng ea tsamaiso li lokela ho nkoa ha ho khethoa foromo e nepahetseng ea litekanyetso.
Tekanyo le tsela ea tsamaiso li bohlokoa ho finyella phello ea phekolo le ho qoba liphello tse mpe. Tekanyetso e lokela ho khethoa ho latela lintlha tse kang mefuta ea liphoofolo, boima ba 'mele, lilemo, boima ba mafu, le thepa ea pharmacokinetic le pharmacodynamic ea lithethefatsi. Ho phaella moo, tsela ea tsamaiso e lokela ho khethoa ho latela lintlha tse kang ho qala ho lakatseha ha ketso, ho monya lithethefatsi le litšobotsi tsa ho aba, le boemo ba 'mele ba phoofolo. Ka bokhutšoanyane, tšebeliso ea lithethefatsi ho phekola mafu a liphoofolo e hloka kutloisiso e felletseng ea liphoofolo, mafu le lithethefatsi. Tsebo ena e kenyelletsa ho nahana ka lintlha tse kang mefuta ea liphoofolo, lilemo, bong, mofuta oa lefu le mafu, mofuta oa litekanyetso, lethal dose, le tsela ea tsamaiso.
Sephutheloana: Sekhechana se seng le se seng se nang le poly bag, likotoana tse 200 tse nang le lebokose la kantle ho naha.
